MersV1, Main, Exploration, bibRecord, 004838

Conservation of HPV‐16 E6/E7 ORF sequences in a cervical carcinoma

Identifieur interne : 004838 ( Main/Exploration ); précédent : 004837; suivant : 004839

Conservation of HPV‐16 E6/E7 ORF sequences in a cervical carcinoma

Auteurs : Richard W. Cone [États-Unis] ; Anthony C. Minson [États-Unis, Royaume-Uni] ; Michael R. Smith [États-Unis] ; James K. Mcdougall [États-Unis]

Source :

Journal of Medical Virology [ 0146-6615 ] ; 1992-06.

RBID : ISTEX:201B86E0F1EAD7BCF216EF3721B610D76D5EB30C

English descriptors

Teeft :
- Bamhi, Bamhi fragment, Base changes, Base pairs, Binding site, Biological activity, Carcinoma, Cell line, Cell lines, Cervical, Cervical cancer, Cervical carcinoma, Cervical carcinomas, Clone, Deletion, Ecori, Fpol region, Fragment, Further study, Genomic, Homology, Human papillomavirus type, Hybridization, Hybridized, Iiii, Incomplete copy, Insertion, Integration site, Integration sites, Long control region, Metastatic, Metastatic tumor, National academy, Normal genomic, Oncogene, Open reading frame, Open reading frames, Opposite strand, Orfs, Original tumor, Papillomavirus, Prototype sequence, Radical hysterectomy, Repetitive element, Repetitive sequences, Restriction digests, Restriction fragments, Restriction sites, Right obturator, Seedorf, Sequence analysis, Sequencing, Sheared salmon sperm, Significant homology, Single band, Single base deletion, Single copy, Southern blot, Subclone, Tumor clone, Tumor subclone, Tumor tissue, Virology, Virology kaur.

Abstract

A cervical carcinoma that contained human papillomavirus (HPV)‐l6 homologous DNA was analyzed. Each tumor cell genome contained a single, incomplete copy of HPV‐16 DNA. The E6 and E7 open reading frames (ORFs) were com‐ pletely conserved relative to other published HPV‐I6 sequences. Much of the non‐coding region (NCR) was free of base changes, including complete conservation of several regulatory elements. Multiple mutations were identified in the remaining integrated HPV‐16 DNA, which was composed of parts of the L1 and E1 ORFs. The extraordinary conservation of the E6/E7 DNA sequence, as compared with other regions of the integrated HPV‐16 DNA, supports the role of E6/E7 in tumorigenesis. © 1992 Wiley‐Liss, Inc.

Url:

https://api.istex.fr/ark:/67375/WNG-3P4G0D5Q-B/fulltext.pdf

DOI: 10.1002/jmv.1890370205

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Istex, to step Checkpoint: 001E20
to stream Main, to step Merge: 004910
to stream Main, to step Curation: 004838

Le document en format XML

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<author><name sortKey="Smith, Michael R" sort="Smith, Michael R" uniqKey="Smith M" first="Michael R." last="Smith">Michael R. Smith</name>
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<author><name sortKey="Mcdougall, James K" sort="Mcdougall, James K" uniqKey="Mcdougall J" first="James K." last="Mcdougall">James K. Mcdougall</name>
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<term>Base pairs</term>
<term>Binding site</term>
<term>Biological activity</term>
<term>Carcinoma</term>
<term>Cell line</term>
<term>Cell lines</term>
<term>Cervical</term>
<term>Cervical cancer</term>
<term>Cervical carcinoma</term>
<term>Cervical carcinomas</term>
<term>Clone</term>
<term>Deletion</term>
<term>Ecori</term>
<term>Fpol region</term>
<term>Fragment</term>
<term>Further study</term>
<term>Genomic</term>
<term>Homology</term>
<term>Human papillomavirus type</term>
<term>Hybridization</term>
<term>Hybridized</term>
<term>Iiii</term>
<term>Incomplete copy</term>
<term>Insertion</term>
<term>Integration site</term>
<term>Integration sites</term>
<term>Long control region</term>
<term>Metastatic</term>
<term>Metastatic tumor</term>
<term>National academy</term>
<term>Normal genomic</term>
<term>Oncogene</term>
<term>Open reading frame</term>
<term>Open reading frames</term>
<term>Opposite strand</term>
<term>Orfs</term>
<term>Original tumor</term>
<term>Papillomavirus</term>
<term>Prototype sequence</term>
<term>Radical hysterectomy</term>
<term>Repetitive element</term>
<term>Repetitive sequences</term>
<term>Restriction digests</term>
<term>Restriction fragments</term>
<term>Restriction sites</term>
<term>Right obturator</term>
<term>Seedorf</term>
<term>Sequence analysis</term>
<term>Sequencing</term>
<term>Sheared salmon sperm</term>
<term>Significant homology</term>
<term>Single band</term>
<term>Single base deletion</term>
<term>Single copy</term>
<term>Southern blot</term>
<term>Subclone</term>
<term>Tumor clone</term>
<term>Tumor subclone</term>
<term>Tumor tissue</term>
<term>Virology</term>
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<front><div type="abstract" xml:lang="en">A cervical carcinoma that contained human papillomavirus (HPV)‐l6 homologous DNA was analyzed. Each tumor cell genome contained a single, incomplete copy of HPV‐16 DNA. The E6 and E7 open reading frames (ORFs) were com‐ pletely conserved relative to other published HPV‐I6 sequences. Much of the non‐coding region (NCR) was free of base changes, including complete conservation of several regulatory elements. Multiple mutations were identified in the remaining integrated HPV‐16 DNA, which was composed of parts of the L1 and E1 ORFs. The extraordinary conservation of the E6/E7 DNA sequence, as compared with other regions of the integrated HPV‐16 DNA, supports the role of E6/E7 in tumorigenesis. © 1992 Wiley‐Liss, Inc.</div>
</front>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Minson, Anthony C" sort="Minson, Anthony C" uniqKey="Minson A" first="Anthony C." last="Minson">Anthony C. Minson</name>
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Conservation of HPV‐16 E6/E7 ORF sequences in a cervical carcinoma

Conservation of HPV‐16 E6/E7 ORF sequences in a cervical carcinoma

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri